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Related Experiment Videos

Inflammation as a basis for functional GI disorders.

R C Spiller1

  • 1Division of Gastroenterology, The Wolfson Digestive Disease Centre, University Hospital, Nottingham NG7 2UH, UK. robin.spiller@nottingham.ac.uk

Best Practice & Research. Clinical Gastroenterology
|August 25, 2004
PubMed
Summary

Functional diseases, often linked to inflammation, can manifest with symptoms like nausea and delayed gastric emptying. Post-infectious functional gastrointestinal disorders may have a better prognosis and respond to anti-inflammatory treatments.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Pathophysiology

Background:

  • Functional diseases present symptoms without overt pathology, but inflammation can cause subtle nerve and mucosal changes.
  • Acute functional dyspepsia and post-infectious irritable bowel syndrome (IBS) are common subtypes.
  • Post-infectious gastroparesis is a rarer condition characterized by delayed gastric emptying.

Purpose of the Study:

  • To explore the underlying mechanisms and characteristics of functional diseases, particularly post-infectious subtypes.
  • To investigate the potential role of inflammation in functional gastrointestinal disorders.
  • To assess the prognosis and treatment response of post-inflammatory functional diseases.

Main Methods:

  • Review of existing literature on functional dyspepsia, IBS, and gastroparesis.

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  • Analysis of symptom presentation, onset, and associated pathologies.
  • Examination of potential therapeutic interventions, including anti-inflammatory treatments.

    • Main Results:

    • Inflammation can underlie functional diseases, with changes detectable by specialized techniques.
    • Acute functional dyspepsia involves early satiety, nausea, and impaired fundal accommodation.
    • Post-infectious IBS is often diarrhea-predominant, and post-infectious gastroparesis involves delayed gastric emptying.
    • Post-inflammatory functional diseases show fewer psychological abnormalities and a better prognosis.

    Conclusions:

    • Functional diseases may have an inflammatory basis, impacting nerve and mucosal function.
    • Post-infectious and post-inflammatory subtypes of functional gastrointestinal disorders warrant further investigation.
    • Anti-inflammatory treatments show anecdotal promise but require controlled trials for validation.