Stereoselective synthesis of nicotinamide beta-riboside and nucleoside analogs
Palmarisa Franchetti1, Michela Pasqualini, Riccardo Petrelli
1Dipartimento di Scienze Chimiche, Università di Camerino, 62032 Camerino, Italy. palmarisa.franchetti@unicam.it
Bioorganic & Medicinal Chemistry Letters
|August 25, 2004
Abstract:
The beta-anomers of N-ribofuranosylnicotine-3-carboxamide (beta-NAR) and its nicotinic acid analog (beta-NaR) were obtained by stereoselective synthesis via glycosylation of the presilylated bases under Vorbruggen's protocol. A NAR analog, methylated in position 3 of the ribosylic moiety, is also reported.
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