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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Physical growth and neurodevelopmental outcome of nonhandicapped low-risk children born preterm
Joachim Pietz1, Johannes Peter, Rainer Graf
1Department of Pediatric Neurology, University of Heidelberg, Im Neuenheimer Feld 150, D-69120 Heidelberg, Germany. Joachim_Pietz@med.uni-heidelberg.de
Insights
Low birth weight (LBW) infants, even those at low risk, show increased growth deficits and subtle neurodevelopmental issues in language and visual-motor skills by age 7. Early follow-up is crucial for timely intervention.
Area of Science:
- Pediatrics
- Neurodevelopmental Pediatrics
- Developmental Psychology
Background:
- Studies on prematurity often exclude low-risk preterm infants.
- Research on low birth weight (LBW) outcomes in less vulnerable populations is limited.
Purpose of the Study:
- To assess growth and neurodevelopmental outcomes in low-risk LBW children up to 7 years of age.
- To compare the long-term development of LBW children with a matched term-born control group.
Main Methods:
- Longitudinal follow-up of 70 low-risk LBW children from birth to 7 years.
- Growth measurements at 20 months and 7 years.
- Neuropsychological assessments at 20 months (Griffiths Scales) and 7 years (comprehensive test battery).
Main Results:
- LBW children exhibited increased low or subnormal growth parameters at 7 years.
- While mean developmental quotients were normal, subtle deficits in language and visual-motor abilities were observed in the LBW group at 7 years.
- Even slightly LBW children (2000-2499g) showed poorer language skills.
Conclusions:
- Low-risk LBW infants experience subtle neurodevelopmental challenges.
- Comprehensive follow-up programs are essential for all LBW infants, including low-risk populations.
- Early detection and intervention before school entry can mitigate potential deficits.
Background:
Outcome studies on the effects of prematurity are increasingly restricted to extremely immature infants with birth weight below 1000 g or gestational age below 26 weeks. In contrast, studies comprising low-risk preterm infants are rare.
Aim:
To examine growth and neurodevelopmental outcome, 70 low-risk low birth weight (LBW) children without neurological impairment were followed from birth to 7 years of age. At 7 years of age, LBW children were compared to a matched control group born at term.
Methods:
Postnatal growth was measured at 20 months in the LBW group and at 7 years in LBW and control children. At 20 months, the LBW group was assessed with the Griffiths Scales. At 7 years, LBW and control children were assessed with a neuropsychological test battery comprising tests for language, visual-perceptual, visual-motor, fine and gross motor abilities.
Results:
At 7 years of age, the frequency of children with low (3rd-9th percentile) or subnormal (<3rd percentile) growth parameters was increased in the LBW group. The Mean Griffiths Developmental Quotient (DQ) of the preterm group was normal (102.3+/-8.4), and there were only two results below DQ 85. There was no difference between 49 children appropriate for gestational age and 21 small for gestational age (SGA) children. At 7 years of age, reduced mean test results in the range of -0.5 SDS were observed for language and visual-motor abilities in the preterm group. This was due to an increased frequency of LBW children with moderately (SDS -1.0 to -2.0 SDS) subnormal test results. Even for the slightly LBW group (2000 to 2499 g), poorer language abilities were confirmed.
Conclusion:
All LBW infants, including low-risk populations, should be included in a follow-up program in order to detect deficits early in life and begin treatment before school entry.
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