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Possible short-term memory loss associated with nafarelin acetate.
C Kortepeter1, M Macmillan, R Ferrell
1Tripler Army Medical Center, Honolulu, HI 96859.
The Annals of Pharmacotherapy
|February 1, 1992
Summary
Nafarelin acetate nasal spray may cause short-term memory loss in some patients. Further research is needed to understand this potential side effect and its relation to hormone therapy.
Area of Science:
- Pharmacology
- Neuroscience
Background:
- Nafarelin acetate is a gonadotropin-releasing hormone agonist.
- Potential side effects of nafarelin acetate are not extensively documented.
Purpose of the Study:
- To investigate the occurrence of short-term memory loss in patients using nafarelin acetate nasal spray.
- To explore the relationship between nafarelin acetate and memory function.
Main Methods:
- A survey was conducted among 16 women using nafarelin acetate nasal spray.
- Patients were assessed on their ability to recall three words before and after a series of questions.
- Patients were asked about their perceived memory changes.
Main Results:
- 56% of patients reported memory difficulties.
- 69% of patients correctly recalled all three words at the end of the survey.
- 13% of patients recalled only one word.
Conclusions:
- Nafarelin acetate nasal spray may be associated with adverse effects on short-term memory.
- Further investigation is warranted into the link between GnRH agonists, estrogen deficiency, menopause, and memory.
- Effective patient-pharmacist communication is crucial for newly marketed medications.