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Updated: Aug 22, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
Complexation of polysaccharide and monosaccharide with thiolate boronic acid capped on silver nanoparticle
Jian Zhang1, Chris D Geddes, Joseph R Lakowicz
1Center for Fluorescence Spectroscopy, University of Maryland School of Medicine, Department of Biochemistry, 725 West Lombard Street, Baltimore, MD 21201, USA. jian@cfs.umbi.umd.edu
Abstract:
Synthesized thiolate boronic acid was found to complex with both a polysaccharide (dextran) and a monosaccharide (glucose) with similar affinities but displayed more affinity with dextran than with glucose when capped as a ligand on silver nanoparticle. Coupling on multiple sites of dextran, the silver particles were aggregated. The aggregated particles displayed a decrease of absorbance at 397 nm and an increase at 640 nm. Luminescence intensity displayed an upward deviation increase with the concentration of dextran. The luminescence spectral change was ascribed to surface-enhanced fluorescence by the enhanced field from the aggregated metallic particles.
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