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Updated: Aug 22, 2026

Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
Solvents and malignancy
Michael J Wernke1, John D Schell
1BBL Sciences, 2940 Kerry Forest Parkway, Suite 102, Tallahassee, FL 32309-6824, USA. mw1@bbl-inc.com
Abstract:
Despite the number of substances that fall under the rubric of solvent, only a few are considered to be potential carcinogens. The purpose of this article is to provide readers with an overview of the cancer data that exist for a number of solvents currently in commercial use. These solvents include chloroform, carbon tetrachloride, methylene chloride (dichloromethane) trichloroethylene, tetrachloroethylene (perchloroethylene), and 1,4-dioxane. Although benzene also would be considered a solvent, the data concerning its carcinogenic potential are presented in another article in this issue and are not discussed in this article.
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