Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intravascular coagulation and osteonecrosis.

J P Jones1

  • 1Diagnostic Osteonecrosis Center, Kelseyville, California.

Clinical Orthopaedics and Related Research
|April 11, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inconclusive decisions and error rates in forensic science.

Forensic science international. Synergy·2024
Same author

222-nm ultraviolet light inactivates dried inocula of human rhinovirus and human coronavirus on a glass carrier.

The Journal of hospital infection·2021
Same author

Outbreak of False Smut of Rice in Louisiana.

Plant disease·2019
Same author

Pathogenicity of Leptographium Species Associated with Loblolly Pine Decline.

Plant disease·2019
Same author

Improving the oral bioavailability of buprenorphine: an in-vivo proof of concept.

The Journal of pharmacy and pharmacology·2016
Same author

Sustained-Release Buprenorphine (RBP-6000) Blocks the Effects of Opioid Challenge With Hydromorphone in Subjects With Opioid Use Disorder.

Journal of clinical psychopharmacology·2015
Same journal

Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.

Clinical orthopaedics and related research·2026
Same journal

Letter to the Editor: Most Contemporary TKA Implant Systems Meet International Benchmark Survivorship Standards: Evidence From a US Registry.

Clinical orthopaedics and related research·2026
Same journal

Reply to the Letter to the Editor: Only Nine Percent of Orthopaedic Clinical Trials Report and One Percent Analyze a Social Determinant of Health: A Systematic Review.

Clinical orthopaedics and related research·2026
Same journal

Letter to the Editor: Isolated Proximal Femoral Valgus Osteotomy for Hinge Abduction Improves Femoroacetabular Relationship in Patients With Perthes Disease.

Clinical orthopaedics and related research·2026
Same journal

Kyphotic Scapular Posture Increases Posterior Deltoid Demand and Acromial-Spine Strain During Shoulder Motion: A Cadaver Study.

Clinical orthopaedics and related research·2026
Same journal

Which Factors Are Associated With Death, Local Recurrence, and Perioperative Complications After En Bloc Resection for Primary Malignant Tumors of the Mobile Spine?

Clinical orthopaedics and related research·2026
See all related articles

Intravascular coagulation (IC) is the likely cause of nontraumatic osteonecrosis (ON) by blocking blood flow. Evidence shows IC leads to bone death, particularly in the femoral head, progressing from fatty necrosis to ischemic degeneration.

Area of Science:

  • Orthopedics
  • Pathology
  • Vascular Biology

Background:

  • Nontraumatic osteonecrosis (ON) is a debilitating condition.
  • The precise mechanism leading to ON remains incompletely understood.
  • Intravascular coagulation (IC) is implicated as a potential pathway.

Purpose of the Study:

  • To investigate the role of intravascular coagulation (IC) as the final common pathway in the pathogenesis of nontraumatic osteonecrosis (ON).
  • To elucidate the progression of ON lesions from early fatty osteocytic necrosis to ischemic degeneration.

Main Methods:

  • Review of current evidence on IC and ON.
  • Analysis of lesion progression from Stage 1A to Stage 1B.
  • Consideration of factors contributing to IC, including fat overload, procoagulants, and impaired fibrinolysis.

Related Experiment Videos

  • Reference to animal models and cartography (embolic scintimetry, angiography).
  • Evaluation of plasma markers (fibrinopeptide A) and histologic findings.

    • Main Results:

    • Intravascular coagulation (IC) is identified as the most probable final common pathway for intraosseous fat embolism-induced osteonecrosis (ON).
    • ON lesion progression is linked to exceeding the ischemic threshold due to subchondral fat overload and impaired clearance of procoagulants.
    • Evidence supports IC initiation in the subchondral microcirculation, leading to devascularization and thrombosis.
    • Increased plasma fibrinopeptide A and histologic findings confirm intraosseous thromboses and IC's role.

    Conclusions:

    • Intravascular coagulation (IC) is the most likely final common pathway in nontraumatic osteonecrosis (ON).
    • The progression of ON involves exceeding ischemic thresholds, leading to IC and subsequent bone death.
    • Evidence from animal studies, imaging, and human cases supports the role of IC in ON pathogenesis.