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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

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A review of the varicella vaccine in immunocompromised individuals

Ana Marli Christovam Sartori1

  • 1Clinic of Infectious and Parasitic Diseases, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, SP, Brazil. amsartori@sti.com.br

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|August 25, 2004
PubMed

Insights

The varicella vaccine is generally not recommended for immunocompromised individuals due to risks of severe illness. However, a review of studies suggests cautious use may be considered in specific cases after thorough risk assessment.

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • Individuals with cell-mediated immunodeficiency face severe risks from varicella-zoster virus.
  • Live-attenuated varicella vaccine is standard for healthy children but generally contraindicated in immunocompromised populations.
  • Limited data exists on varicella vaccination in immunocompromised individuals.

Purpose of the Study:

  • To review existing literature on varicella vaccine use in patients with cell-mediated immunodeficiency disorders.

Main Methods:

  • A comprehensive literature search was conducted using the PubMed database.
  • Relevant studies published up to March 2003 were included.

Main Results:

  • Extensive research exists for varicella vaccination in children with acute lymphoblastic leukemia in remission.
  • Studies on varicella vaccination in other immunodeficiency disorders are limited and often based on small sample sizes with short follow-up periods.
  • Current recommendations for varicella vaccination in immunocompromised individuals are based on scarce evidence.

Conclusions:

  • The varicella vaccine should only be administered to immunocompromised individuals after a thorough understanding of their clinical and immunological status.
  • A careful evaluation of the risks associated with both natural varicella infection and vaccination is crucial before administration.
Abstract

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