Influence of cellularity in human breast carcinoma

Ninty-three cases of both invasive ductal and lobular carcinoma were examined to clarify the relationship between the clinicopathological factors and cellularity (cell density) or total cancer cells number in carcinoma tissues. The cellularity showed significant correlation with tumor size and vascular invasion, but not with other clinicopathological factors (menopausal status, operation method, ER status, histological grade or type, lymph node stage) and prognosis. The total cancer cell number revealed a positive relationship with survival (overall survival) and disease-free interval (DFI) by univariate analysis, even though it did not show any positive correlation with other clinicopathological factors in this study. Moreover, it was not found to have any stronger impact than other previously reported prognostic factors such as tumor size, lymph node stage or tumor grade by multivariate analysis. From these evidences, we speculate that the cellularity correlates with expansion or invasion of tumor cells and the total number of cancer cells reflects the prognosis of the tumor-bearing host, although it does not play a major role in prediction.