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Published on: November 2, 2016
Use of a modified microplate bioassay method to investigate antibacterial activity in the Peruvian medicinal plant
Richard D Langfield1, Frank J Scarano, Mary E Heitzman
1Department of Chemistry and Biochemistry, University of Massachusetts-Dartmouth, North Dartmouth 02747, USA.
Abstract:
A versatile microplate bioassay for quick and sensitive determination of antibacterial activity was developed for use in screening medicinal plants and identification of their active principles. This assay can be used to determine minimum inhibitory concentrations for small quantities of organic or water-soluble plant extracts. Bioassay-guided fractionation of the stem and leaves of Peperomia galioides using this method found fractions containing grifolin and grifolic acid, which inhibited growth of Staphylococcus aureus and Staphylococcus epidermidis.
