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Routine terminations of pregnancy--should we screen for gestational trophoblastic neoplasia?

Michael J Seckl1, Roopinder Gillmore, Marianne Foskett

  • 1Gestational Trophoblastic Disease Unit, Department of Medical Oncology, Charing Cross and Hammersmith Hospitals Campus, Imperial College London, Fulham Palace Road, London W6 8RF, UK. m.seckl@imperial.co.uk

Lancet (London, England)
|August 25, 2004
PubMed

After termination of pregnancy for non-medical reasons, the products of conception are often not routinely examined for gestational trophoblastic neoplasia. Between 1995 and 2001 we identified 15 women without and 36 women with a pathological diagnosis of gestational trophoblastic neoplasia at the time of their pregnancy termination. Women without a diagnosis were significantly more likely to have subsequent life-threatening complications of gestational trophoblastic neoplasia (four of 15 vs none of 36; p=0.003), and to require surgical intervention (15 of 15 vs one of 36; p<0.0001) and chemotherapy (nine of 15 vs two of 36; p<0.0001). All women should be screened for gestational trophoblastic neoplasia after termination of pregnancy.

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