Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability
S Amemiya1, A Sekizawa, J Otsuka
1Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo, Japan.
Objectives:
To clarify the role of specific genetic alterations in the multi-step process of malignant transformation of endometriosis.
Methods:
In cases of ovarian endometrioid carcinoma, we separated regions of normal endometriosis, atypical endometriosis and ovarian endometrioid carcinoma by laser microdissection, and examined K-ras mutation and microsatellite instability in each separated tissue sample.
Results:
We detected K-ras mutation and microsatellite instability in endometrioid carcinoma tissue, but not in normal or atypical endometriosis bordering the cancerous region.
Conclusions:
The present findings suggest that K-ras mutation and microsatellite instability are associated with malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma.
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