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Carotenoids and transcription

Yoav Sharoni1, Michael Danilenko, Noga Dubi

  • 1Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev and Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel. yoav@bgumail.bgu.ac.il

Archives of Biochemistry and Biophysics
|August 25, 2004
PubMed

Insights

Carotenoids, potent antioxidants, exhibit anticancer properties by influencing cell growth and protein expression. This review highlights their role in modulating key transcription systems, offering a molecular basis for their therapeutic potential.

Area of Science:

  • Nutritional biochemistry
  • Molecular oncology
  • Cellular signaling

Background:

  • Carotenoids are natural compounds with documented anticancer activities.
  • Their mechanisms involve modulating cell proliferation, growth factor signaling, and intercellular communication.
  • Changes in protein expression suggest a role in regulating gene transcription.

Purpose of the Study:

  • To review the involvement of various transcription systems in the anticancer effects of carotenoids.
  • To explore how carotenoids modulate cellular processes through transcription factors.
  • To provide a molecular framework for understanding carotenoid-mediated anticancer activity.

Main Methods:

  • Literature review of studies investigating carotenoid effects on cellular mechanisms.
  • Analysis of evidence for the involvement of specific transcription systems.
  • Synthesis of findings on protein expression modulation by carotenoids.

Main Results:

  • Carotenoids influence cell proliferation, growth factor signaling, and gap junctional communication.
  • Evidence supports the role of retinoid receptors, AP-1, PPAR, xenobiotic receptors, and ARE in carotenoid anticancer activity.
  • Carotenoids modulate the expression of multiple proteins involved in these cellular processes.

Conclusions:

  • Carotenoids exert anticancer effects by modulating a network of transcription systems.
  • This modulation of transcription provides a molecular basis for their biological activity.
  • Combinations of carotenoids with other compounds may enhance synergistic anticancer effects.

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