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Sustained remission of CIDP associated with Evans syndrome
Hans Knecht1, Michael Baumberger, Aurelio Tobòn
1Institute for Clinical Research, Swiss Paraplegic Centre, CH-6207 Nottwil (Lucerne), Switzerland. hans.knecht@paranet.ch
Abstract:
A patient with chronic inflammatory demyelinating polyneuropathy (CIDP) developed Evans syndrome (hemolytic anemia/thrombocytopenia) 17 months after onset of symptoms despite different immunomodulatory treatments. A therapeutic approach with the chimeric monoclonal anti-CD20 antibody rituximab induced substantial improvement of CIDP and hematologic recovery. The patient remains in sustained remission 17 months after completion of therapy. Rituximab may represent a successful therapy in otherwise refractory CIDP.
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