Related Experiment Video
Updated: Aug 22, 2026
In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection
Published on: November 27, 2014
CD8+ T cells reduce in vitro interferon-gamma production in Theiler's murine encephalomyelitis virus-induced
Paul W Denton1, Christina M Tello, Roger W Melvold
1Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203-9037, USA.
In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8+ T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-gamma production by anti-TMEV CD4+ blast cells in BALB/c mice. We describe here that regulatory CD8+ T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.
In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8+ T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-gamma production by anti-TMEV CD4+ blast cells in BALB/c mice. We describe here that regulatory CD8+ T cells reduce in vitro IFN-gamma production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-beta or tumour necrosis factor-alpha production.
