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Clinical impact of intravenous methylprednisolone in attacks of multiple sclerosis

Carlos Nos¹, Jaume Sastre-Garriga, Cecília Borràs

¹Unitat de Neuroimmunologia Clínica, Hospital Vall d'Hebron, Barcelona, Spain.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|August 26, 2004

Abstract

Background:

Intravenous methylprednisolone (IVMP) has been shown to hasten recovery from attacks of multiple sclerosis (MS) without altering the long term evolution of the condition; however, there is little evidence available to suggest which patients are more likely to benefit from IVMP treatment.

Objective:

To measure clinical change after IVMP treatment and to identify predictors of good outcome.

Methods:

Retrospective open-label study of medical records from 51 patients with clinically isolated syndromes or relapsing-remitting MS treated with IVMP for an acute attack (54 attacks).

Results:

A measurable neurological improvement was observed at one month in 44% of these attacks; the only predictor of Expanded Disability Status Scale (EDSS) change at one month was the severity of the attack.

Conclusion:

Attack severity predicts good response to IVMP when measured by means of EDSS.

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