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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

[A clinical and pathothysiological study of protein C in patients with generalized meningococcosis]

E A Gorodnova, S G Pak, V A Malov

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |August 26, 2004
    PubMed

    Insights

    Low protein C levels in meningococcemia patients indicate disease severity and risk of disseminated intravascular coagulation (DIC). Protein C monitoring aids in assessing anticoagulation and thrombohemorrhagic syndrome risk.

    Area of Science:

    • Hematology
    • Infectious Diseases

    Context:

    • Meningococcemia is a severe bacterial infection.
    • Protein C plays a crucial role in regulating blood coagulation.

    Purpose:

    • To investigate the clinical and pathogenetic significance of protein C in meningococcemia.
    • To assess the correlation between protein C levels, disease severity, and complications like DIC.

    Summary:

    • A study of 23 meningococcemia patients revealed significantly lower protein C concentrations during exacerbation (mean 37.8%) compared to normal levels (70-130%).
    • Leyden mutation was found in 30.5% of patients, predisposing them to severe disseminated intravascular coagulation (DIC).
    • Lower protein C levels correlated with increased infection severity and organ dysfunction, highlighting its role in evaluating thrombohemorrhagic syndrome.

    Impact:

    • Protein C concentration serves as a valuable indicator for assessing anticoagulation mechanisms and the risk of thrombohemorrhagic complications in meningococcemia.
    • This research provides insights into the pathogenetic role of protein C in severe infections, aiding clinical management.

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