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Immunomodulation by probiotic lactobacilli in layer- and meat-type chickens.
M E Koenen1, J Kramer, R van der Hulst
1Animal Sciences Group, Wageningen UR, Division of Animal Resources Development, Lelystad, the Netherlands. marjorie.koenen@wur.nl
British Poultry Science
|August 26, 2004
Summary
Selected probiotic lactobacillus strains modulate immune responses in chickens. Optimal effects depend on chicken type, age, dose, and feeding regimen for enhanced immunity.
Area of Science:
- Veterinary Immunology
- Microbiology
- Poultry Science
Background:
- Probiotics, particularly Lactobacillus strains, are increasingly recognized for their potential to modulate host immune responses.
- Understanding the specific immunomodulatory effects of different probiotic strains in various chicken types (layer vs. meat) is crucial for optimizing poultry health and productivity.
Purpose of the Study:
- To investigate and compare the immunomodulating effects of selected Lactobacillus strains in layer-type and meat-type chickens.
- To evaluate the influence of different feeding regimes (short and continuous) and administration doses on the efficacy of these probiotic lactobacilli.
Main Methods:
- Assessment of humoral and cellular immune responses, including cellular proliferation assays.
- Evaluation of Salmonella enterica invasion and survival in gut and spleen leukocytes.
- Quantification of immunoglobulin isotypes and specific antibody titers.
Main Results:
- Lactobacillus strains demonstrated distinct immunomodulatory effects in both layer and meat-type chickens.
- In meat-type chickens, a high dose and early administration (up to 3 weeks) showed a stimulating effect.
- In layer-type chickens, a lower dose and discontinuous administration proved effective.
Conclusions:
- Immunoprobiotic lactobacilli can positively influence humoral and cellular immunity in both layer and meat-type chickens.
- Optimizing the choice of Lactobacillus strain, animal age, and dosage is essential for maximizing the beneficial effects of immunobiotics in poultry.