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Serial S100B levels before, during and after cerebral herniation
J Undén1, J Bellner, P Reinstrup
1Department of Neurosurgery, Lund University Hospital, Lund, Sweden.
British Journal of Neurosurgery
|August 26, 2004
Summary
Serum S100B protein levels may indicate cerebral herniation in trauma patients. Extracerebral sources also contribute to S100B levels, particularly during organ harvesting.
Area of Science:
- Neurology
- Biochemistry
Background:
- Protein S100B elevates in serum and cerebrospinal fluid (CSF) during neurological diseases.
- The role of S100B in cerebral herniation and extracerebral sources remains understudied.
Observation:
- A multi-trauma patient experienced cerebral herniation and underwent organ harvesting.
- Serial serum S100B levels were monitored during herniation and subsequent extracerebral surgery.
Findings:
- Serum S100B peaked just before cerebral herniation, suggesting a primary cerebral origin.
- S100B levels increased during organ harvesting, indicating extracerebral protein sources.
Implications:
- Serum S100B may serve as a biomarker for cerebral herniation in trauma.
- Understanding both cerebral and extracerebral S100B sources is crucial for clinical interpretation.