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Complementary peptide epitopes and anti-idiotypic antibodies in autoimmunity
Maria Sakarellos-Daitsiotis1, Manh-Thong Cung, Constantinos Sakarellos
1Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Protein and Peptide Letters
|August 26, 2004
Abstract:
Application of complementary B and T cell epitopes in inducing anti-idiotypic and anti-clonotypic antibodies capable of regulating or suppressing the autoimmune responses in experimental autoimmune myasthenia gravis (EAMG), allergic neuritis (EAN) and allergic encephalomyelitis (EAE) has been the stimulus of many research efforts. Studies on the idiotypic/anti-idiotypic network of anti-La/SSB positive sera from patients with Sjogren's Syndrome (SS) and Systemic Lupus Erythematosus (SLE) and on animals immunized with the complementary epitopes are presented.