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Osteoporosis and Klinefelter's syndrome
M Horowitz1, J M Wishart, P D O'Loughlin
1Department of Medicine, Royal Adelaide Hospital, South Australia.
Clinical Endocrinology
|January 1, 1992
Summary
Patients with Klinefelter's syndrome exhibit lower forearm bone density and altered biochemical markers. These changes suggest reduced bone formation and increased resorption, impacting bone health in this population.
Area of Science:
- Endocrinology
- Bone Metabolism
- Genetics
Background:
- Klinefelter's syndrome (KS) is a genetic condition affecting males, often associated with hypogonadism.
- Bone density and metabolic alterations are potential complications of KS.
Purpose of the Study:
- To assess forearm bone mineral density (BMD) and related biochemical markers in individuals with KS.
- To compare these measurements with age-matched healthy male controls.
Main Methods:
- Studied 22 patients with KS (12 on hormone therapy) and 22 controls.
- Measured forearm BMD, fat content, calcium levels, and bone turnover markers (osteocalcin, DHEA-S, hydroxyproline/creatinine).
Main Results:
- KS patients had significantly lower forearm BMD and higher fat content.
- Lower serum osteocalcin and testosterone, higher ionized calcium, and elevated urinary hydroxyproline/creatinine were observed in KS.
- BMD correlated with testosterone levels in KS patients.
Conclusions:
- Approximately 25% of KS patients experience decreased bone density.
- This bone loss is likely due to a combination of reduced bone formation and increased bone resorption.