Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histone deacetylase inhibitors.

Paul A Marks1, Victoria M Richon, Thomas Miller

  • 1Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Advances in Cancer Research
|August 26, 2004
PubMed
Summary

Histone deacetylase inhibitors (HDACi) offer a promising avenue for cancer therapy by modulating gene expression through epigenetic modifications. Clinical trials demonstrate their well-tolerated antitumor activity in various cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spider leg biomechanics as an information filter for vibration sensing.

Proceedings. Biological sciences·2026
Same author

Early Neurodevelopmental Outcomes in Children With Congenital Heart Disease.

JAMA network open·2026
Same author

Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells.

Molecular cell·2026
Same author

A Comparison of F/TAF and F/TDF as HIV Pre-Exposure Prophylaxis in a Predominantly Cisgender Women Population in East and South Africa: A Randomized, Factorial, Noninferiority Trial.

Journal of acquired immune deficiency syndromes (1999)·2026
Same author

Three-Year Outcomes of Intravitreal Aflibercept versus Laser Therapy for Retinopathy of Prematurity: Interim Analysis of the Efficacy and Safety Outcomes in the FIREFLEYE next Trial.

Neonatology·2026
Same author

Correction: Adherence to recommended practices for perioperative anesthesia care for older adults among US anesthesiologists: results from the ASA Committee on Geriatric Anesthesia-Perioperative Brain Health Initiative ASA member survey.

Perioperative medicine (London, England)·2025

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cancer Research

Background:

  • Gene transcription regulation is influenced by chromatin structure, known as epigenetic gene regulation.
  • Posttranslational histone modifications, particularly acetylation/deacetylation by histone deacetylases (HDACs) and histone acetyltransferases (HATs), are crucial for gene expression control.
  • Dysregulation of HATs and HDACs is implicated in the development of numerous cancers.

Purpose of the Study:

  • To investigate the therapeutic potential of histone deacetylase inhibitors (HDACi) in cancer treatment.
  • To evaluate the effects of HDACi on cancer cell growth, differentiation, and apoptosis.
  • To assess the clinical efficacy and tolerability of HDACi in cancer patients.

Main Methods:

  • Development of structurally diverse HDAC inhibitors (HDACi).

Related Experiment Videos

  • In vitro and in vivo studies using cancer cell lines and tumor-bearing animal models.
  • Clinical trials to evaluate antitumor activity and patient tolerability.

    • Main Results:

    • HDAC inhibitors induce growth arrest, differentiation, and/or apoptosis in cancer cells.
    • Preclinical studies show efficacy in both in vitro and in vivo models.
    • Clinical trials indicate that certain HDACi possess significant antitumor activity against various cancers with good tolerability.

    Conclusions:

    • HDAC inhibitors represent a viable therapeutic strategy for cancer treatment.
    • The modulation of epigenetic modifications via HDAC inhibition offers a promising approach for cancer therapy.
    • Further clinical investigation of HDACi is warranted for diverse oncological indications.