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[Diagnostics of larval toxocariasis].

Miroslav Förstl1, Vladimír Buchta, Jirí Psohlavec

  • 1Institute of Clinical Microbiology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic. forstlm@lfhk.cuni.cz

Klinicka Mikrobiologie a Infekcni Lekarstvi
|August 26, 2004
PubMed
Summary

This study found a 20.4% immunity rate for human toxocariasis in Eastern Bohemia, with prevalence increasing with age and shifting towards women after age 30. Serological IgG antibody testing remains a valuable diagnostic tool.

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Area of Science:

  • Medical Parasitology
  • Immunology
  • Epidemiology

Context:

  • Larval toxocariasis is a neglected zoonotic disease caused by Toxocara species.
  • Serological detection of IgG antibodies is a primary diagnostic method.
  • Understanding regional prevalence and demographic risk factors is crucial for public health.

Purpose:

  • To determine the prevalence of serum IgG antibodies against Toxocara canis in patients suspected of larval toxocariasis.
  • To analyze the relationship between IgG positivity, age, and sex.
  • To evaluate physician demand for toxocariasis testing and assess IgG avidity detection.

Summary:

  • A retrospective study analyzed 2,994 sera from Eastern Bohemia (1997-2002) using ELISA for IgG antibodies against Toxocara canis.

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  • The overall IgG positivity rate was 20.4%, increasing with age. Prevalence shifted from predominantly males in younger age groups to females after the third decade.
  • Low IgG avidity was found in 6.5% of positive samples. Physician requests for testing increased over the study period without a corresponding rise in positivity rates.
  • Impact:

    • Provides regional epidemiological data on human toxocariasis in the Czech Republic.
    • Highlights age and sex as significant demographic factors influencing infection rates.
    • Reinforces the utility of serological IgG antibody testing in routine diagnostics.