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Cognitive dysfunction in patients with small-cell lung cancer: incidence, causes, and suggestions on management
Anne Kanard1, Stephen Frytak, Aminah Jatoi
1Department of Oncology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Abstract:
Cognitive dysfunction is a common occurrence among patients with small-cell lung cancer, with prevalence rates ranging anywhere from 15% to 90%. Although prophylactic cranial irradiation has been described as one culprit to explain these cognitive deficits, other causes also have been implicated. This review provides a summary of the factors that may contribute to cognitive decline in this group of patients and comments upon how cognitive dysfunction or the risk for it might influence patient management.
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