Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial serial order processing in schizophrenia.

David Fraser1, Sohee Park, Gina Clark

  • 1Department of Physiology, Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, 303 East Chicago Ave., Ward 5-132, Chicago, IL 60611, USA.

Schizophrenia Research
|August 27, 2004
PubMed
Summary

Schizophrenia patients exhibit significant working memory deficits, struggling to recall sequences even at low memory loads. This impairment, affecting serial order processing, is more pronounced than in healthy individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Four-Strand Short Graft Failure Loads of Half-Peroneus Longus Tendon Grafts Compared With Full Semitendinosus Tendon Grafts.

Orthopaedic journal of sports medicine·2026
Same author

Mucosal Inflammation Shapes Human Neutrophil States in Tissue and Circulation.

bioRxiv : the preprint server for biology·2026
Same author

Oral lichenoid lesions in CTLA-4 haploinsufficiency: Targeting IFN-γ-driven mucosal immunopathology.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Distinct spatial organization governs oral mucosal immunity.

Nature immunology·2026
Same author

Evaluating the Real-World Implementation and Effectiveness of a Collaborative Care Model for Adults with Depression and Anxiety at an Urban, Academic Hospital.

Journal of evaluation in clinical practice·2025
Same author

A quantitative analysis of the hip shuck test during robotic arm-assisted total hip arthroplasty.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2025

Area of Science:

  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Schizophrenia is associated with cognitive impairments, particularly in working memory.
  • Serial order processing is a critical component of working memory, often affected in psychiatric disorders.

Purpose of the Study:

  • To investigate serial order processing deficits in schizophrenia patients.
  • To compare working memory performance in schizophrenia patients and healthy controls using a spatial task.

Main Methods:

  • A spatial serial order working memory task was administered to 21 schizophrenia patients and 16 healthy controls.
  • Participants recalled the location and order of 1-4 spatial targets presented sequentially.
  • Performance was analyzed based on sequence length and target position.

Related Experiment Videos

Main Results:

  • Schizophrenia patients demonstrated a marked deficit in recalling spatial sequences compared to controls.
  • Memory performance declined with increasing sequence length for both groups, but significantly more in patients.
  • Patients made more errors in target choice, indicating a specific deficit in serial order recall, not motor control.

Conclusions:

  • Schizophrenia patients exhibit significant impairments in serial order working memory.
  • Working memory network saturation at low memory loads may underlie these deficits in schizophrenia.
  • Findings highlight the vulnerability of sequential memory in schizophrenia, especially with increased cognitive load.