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Related Experiment Videos

Resveratrol-associated renal toxicity.

James A Crowell1, Peter J Korytko, Robert L Morrissey

  • 1Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland 20892-7322, USA. jc94h@nih.gov

Toxicological Sciences : an Official Journal of the Society of Toxicology
|August 27, 2004
PubMed
Summary
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Resveratrol toxicity studies in rats revealed adverse effects, primarily at high doses (3000 mg/kg). The no observed adverse effect level for resveratrol was determined to be 300 mg/kg body weight in rats.

Area of Science:

  • Toxicology
  • Pharmacology
  • Nutraceuticals

Background:

  • Resveratrol, a natural compound, exhibits potential health benefits including cardiovascular and cancer preventive activities.
  • It is currently under development for various clinical applications.

Purpose of the Study:

  • To evaluate the potential toxicity of trans-resveratrol in rats.
  • To determine the no observed adverse effect level (NOAEL) of resveratrol.

Main Methods:

  • Rats were administered varying doses of trans-resveratrol (0, 300, 1000, 3000 mg/kg/day) via gavage for 4 weeks.
  • Clinical signs, body weight, food consumption, clinical chemistry, hematology, and histopathology were assessed.

Main Results:

  • Adverse effects, including toxicity signs, reduced body weight, altered clinical chemistry (elevated BUN, creatinine, liver enzymes), hematological changes, and kidney lesions, were observed predominantly at 3000 mg/kg.

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  • The no observed adverse effect level (NOAEL) was established at 300 mg/kg/day.
  • Some effects like reduced weight gain and elevated white blood cell counts were noted at 1000 mg/kg in a dose- and sex-dependent manner.

    • Conclusions:

    • Resveratrol exhibits dose-dependent toxicity in rats, with significant adverse effects at 3000 mg/kg.
    • The NOAEL for resveratrol in this rat study is 300 mg/kg/day.
    • Further investigation may be warranted for lower doses and specific clinical indications.