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Updated: Aug 22, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
From IHF protein to design and synthesis of a sequence-specific DNA bending peptide
Eduard K Liebler1, Ulf Diederichsen
1Institut für Organische und Biomolekulare Chemie, Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Abstract:
The design and synthesis of a small peptide that mimics the integration host factor (IHF), a major nucleoid-associated protein, is reported. IHF induces DNA compaction by sequence-specific binding that leads to significant bending of the DNA double strand. In a modular approach a small L-lysine dendrimer responsible for nonspecific charge-charge interactions was linked to a cyclopeptide. The latter was designed for specific DNA recognition in the minor groove followed by bending of the double strand.
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