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Related Experiment Videos

Intra-abdominal synovial sarcoma: a clinicopathological study.

C Fisher1, A L Folpe, H Hashimoto

  • 1Department of Anatomic Pathology, Royal Marsden Hospital, London, UK. cyril.fisher@icr.ac.uk

Histopathology
|August 28, 2004
PubMed
Summary
This summary is machine-generated.

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Intra-abdominal synovial sarcomas are rare, aggressive tumors that often recur locally. Pelvic tumors may metastasize distantly, while retroperitoneal tumors tend to remain localized, but both have high mortality rates.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Imaging

Background:

  • Synovial sarcoma is a rare soft tissue sarcoma.
  • Intra-abdominal, pelvic, and retroperitoneal locations are uncommon for synovial sarcoma.
  • These tumors can be misdiagnosed as other spindle or round cell sarcomas.

Purpose of the Study:

  • To evaluate the characteristics and outcomes of synovial sarcomas in the abdomen, pelvis, and retroperitoneum.
  • To differentiate these tumors from other intra-abdominal malignancies.
  • To analyze recurrence patterns and survival rates.

Main Methods:

  • Retrospective review of 11 intra-abdominal synovial sarcomas from two referral practices.
  • Histopathological analysis including grading and molecular subtyping (SYT-SSX2 fusion gene).

Related Experiment Videos

  • Clinical data review including tumor size, location, treatment, and follow-up.

    • Main Results:

    • 11 cases represented 3.7% of all synovial sarcomas seen.
    • Tumors occurred in middle-aged adults (mean 49 years), were large (mean 210 mm), and predominantly high-grade.
    • Local recurrence was common (90%), with pelvic tumors metastasizing distantly, and high mortality (80% within 36 months).

    Conclusions:

    • Intra-abdominal synovial sarcomas are rare, aggressive, and challenging to resect.
    • Local recurrence is frequent, and distant metastasis occurs with pelvic tumors.
    • Despite confined spread of retroperitoneal tumors, overall survival is poor.