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Related Experiment Videos

Intra-abdominal synovial sarcoma: a clinicopathological study.

C Fisher1, A L Folpe, H Hashimoto

  • 1Department of Anatomic Pathology, Royal Marsden Hospital, London, UK. cyril.fisher@icr.ac.uk

Histopathology
|August 28, 2004
PubMed
Summary

Intra-abdominal synovial sarcomas are rare, aggressive tumors that often recur locally. Pelvic tumors may metastasize distantly, while retroperitoneal tumors tend to remain localized, but both have high mortality rates.

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Histopathology·2004

Area of Science:

  • Oncology
  • Surgical Pathology
  • Medical Imaging

Background:

  • Synovial sarcoma is a rare soft tissue sarcoma.
  • Intra-abdominal, pelvic, and retroperitoneal locations are uncommon for synovial sarcoma.
  • These tumors can be misdiagnosed as other spindle or round cell sarcomas.

Purpose of the Study:

  • To evaluate the characteristics and outcomes of synovial sarcomas in the abdomen, pelvis, and retroperitoneum.
  • To differentiate these tumors from other intra-abdominal malignancies.
  • To analyze recurrence patterns and survival rates.

Main Methods:

  • Retrospective review of 11 intra-abdominal synovial sarcomas from two referral practices.
  • Histopathological analysis including grading and molecular subtyping (SYT-SSX2 fusion gene).

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  • Clinical data review including tumor size, location, treatment, and follow-up.

    • Main Results:

    • 11 cases represented 3.7% of all synovial sarcomas seen.
    • Tumors occurred in middle-aged adults (mean 49 years), were large (mean 210 mm), and predominantly high-grade.
    • Local recurrence was common (90%), with pelvic tumors metastasizing distantly, and high mortality (80% within 36 months).

    Conclusions:

    • Intra-abdominal synovial sarcomas are rare, aggressive, and challenging to resect.
    • Local recurrence is frequent, and distant metastasis occurs with pelvic tumors.
    • Despite confined spread of retroperitoneal tumors, overall survival is poor.