Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C-KIT expression in primary cutaneous T-cell lymphomas.

Tilmann C Brauns1, Thomas Schultewolter, Joachim Dissemond

  • 1Department of Dermatology, University of Essen, Essen, Germany. tilmannbrauns@aol.com

Journal of Cutaneous Pathology
|August 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adjunctive optical and magnetic stimulation for venous and mixed etiology leg ulcers: protocol for the NAZARÉ multicenter randomized controlled trial.

Trials·2026
Same author

Cutaneous leukocytoclastic vasculitis as acute hemorrhagic edema in a 71-year-old patient.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Therapy with lebrikizumab for refractory peristomal irritant contact dermatitis.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

S1 Guideline on Infected Interdigital Intertrigo (also called Gram-Negative Toe Web Infection).

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

pH profiling reveals progressive wound acidification during healing and higher pH in chronic non-healing wounds: a prospective, multicenter cohort study.

Scientific reports·2026
Same author

Minimum Data Set for Treatment Effectiveness in Pyoderma Gangrenosum for an International Registry: An International Multidisciplinary eDelphi Consensus.

The British journal of dermatology·2026
Same journal

Blastic Plasmacytoid Dendritic Cell Neoplasm.

Journal of cutaneous pathology·2026
Same journal

Atypical Grover Disease Associated With Merkel Cell Carcinoma: A Novel Paraneoplastic Presentation.

Journal of cutaneous pathology·2026
Same journal

Profile of a Founder: Herbert Zachareus Lund.

Journal of cutaneous pathology·2026
Same journal

The National Resident Match Program Arrives in Dermatopathology: 15 Years of Resilient Advocacy by the American Society of Dermatopathology's Fellowship Training Program Directors' Committee.

Journal of cutaneous pathology·2026
Same journal

Evaluating Large Language Models for Melanocytic Lesion Pathology Report Interpretation.

Journal of cutaneous pathology·2026
Same journal

An Atypical Skin Presentation of Adult-Onset Still's Disease With Histological Description: A Case Report.

Journal of cutaneous pathology·2026
See all related articles

C-KIT receptor expression is rare in most primary cutaneous T-cell lymphomas (TCLs), limiting its therapeutic potential. This study investigated C-KIT presence in various TCL subtypes, finding only weak expression in a small cell population.

Area of Science:

  • Oncology
  • Dermatology
  • Molecular Biology

Background:

  • Mutations in the stem cell factor receptor C-KIT are implicated in various cancers.
  • C-KIT expression is known in certain hematologic malignancies and lymphomas.
  • Kinase inhibitors targeting C-KIT offer potential therapeutic avenues.

Purpose of the Study:

  • To screen over 50 types of cutaneous T-cell lymphomas (TCLs) for C-KIT expression.
  • To evaluate the potential of C-KIT as a therapeutic target in primary cutaneous lymphomas.

Main Methods:

  • Immunohistochemical staining of paraffin-embedded tissue sections.
  • Utilized a polyclonal rabbit anti-human C-KIT antibody.
  • Performed Naphtol-ASD-chloroacetate esterase (NASDCE) control stainings to differentiate lymphoma cells from mast cells.

Related Experiment Videos

Main Results:

  • Weak C-KIT expression was detected in a small population of lymphoma cells in specific TCL subtypes.
  • Positive findings included primary cutaneous CD30+ ALCL (7/18), primary cutaneous pleomorphic TCL (2/8), mycosis fungoides (6/18), and Sezary's syndrome (3/5).
  • C-KIT expression was generally rare across all investigated primary cutaneous lymphoma types.

Conclusions:

  • C-KIT expression is infrequent in primary cutaneous T-cell lymphomas.
  • The limited expression suggests C-KIT may not be a broadly applicable therapeutic target for these conditions.
  • Further research is needed to fully understand C-KIT's role and therapeutic potential in TCLs.