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Updated: Aug 22, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Inherited interstitial lung disease
Christine Kim Garcia1, Ganesh Raghu
1Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Building NB10.210A, Mail Code 8591, Dallas, TX 75390, USA. Christine.Garcia@UTSouthwestern.edu
Abstract:
This article focuses on recent advances in the identification of genes and genetic polymorphisms that have been implicated in the development of human interstitial lung diseases. It focuses on the inherited mendelian diseases in which pulmonary fibrosis is part of the clinical phenotype and the genetics of familial idiopathic pulmonary fibrosis and other rare inherited interstitial lung diseases. The article also reviews the association studies that have been published to date regarding the genetics of sporadic idiopathic pulmonary fibrosis. The reader is directed to recent reviews on human genetic predisposition of sarcoidosis, environmental-related, drug-related, connective tissue related pulmonary fibrosis, and genetic predisposition of fibrosis in animal models.
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