Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Minireview: Cyclin D1: normal and abnormal functions.

Maofu Fu1, Chenguang Wang, Zhiping Li

  • 1Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, DC 20057-1468, USA.

Endocrinology
|August 28, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing Machine Learning-Based Predictive Models for Hallux Valgus Recurrence Based on Measurements From Radiographs.

Foot & ankle international·2024
Same author

Diverse functions and pathogenetic role of Crumbs in retinopathy.

Cell communication and signaling : CCS·2024
Same author

Enhancing Global Estimation of Fine Particulate Matter Concentrations by Including Geophysical <i>a Priori</i> Information in Deep Learning.

ACS ES&T air·2024
Same author

Macrophage membrane-coated nanoparticles for the treatment of infectious diseases.

Biomedical materials (Bristol, England)·2024
Same author

Study on the secondary oxidation behavior and microscopic characteristics of oxidized coal gangue.

Environmental science and pollution research international·2024
Same author

Delaying the first nucleation event of amorphous solid dispersions above the polymer overlap concentration (c*): PVP and PVPVA in posaconazole.

Journal of pharmaceutical sciences·2024
Same journal

Zingerone ameliorates ovarian impairment by regulating steroidogenesis and apoptosis in letrozole-treated mouse.

Endocrinology·2026
Same journal

Loss of the calorie restriction response protein DEPP1 worsens diet-induced obesity.

Endocrinology·2026
Same journal

Long Non-Coding RNAs Mediate Endocrine Signaling and Resistance in Prostate Cancer.

Endocrinology·2026
Same journal

Repeated Chemogenetic Activation of C1 Catecholamine Neurons Reduces Subsequent Glucoprivic Responses and Mimics HAAF.

Endocrinology·2026
Same journal

Postnatal exposure to maternal hypothyroidism leads to developmental delay and metabolic dysregulations in male mice.

Endocrinology·2026
Same journal

Discovery proteomics identification of factors contributing to gonadotropin β expression.

Endocrinology·2026
See all related articles

Cyclin D1, a key cell cycle regulator, is implicated in various cancers. Emerging research highlights its novel, cyclin-dependent kinase-independent roles in tumorigenesis.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cyclin D1 is a regulatory protein controlling cell cycle progression by phosphorylating the retinoblastoma protein.
  • Overexpression of cyclin D1 is linked to the development of several human cancers, including breast, prostate, and melanoma.
  • While traditionally viewed as a cyclin-dependent kinase (CDK)-dependent regulator, novel functions are emerging.

Purpose of the Study:

  • To review the established and novel functions of cyclin D1.
  • To emphasize the cell cycle or CDK-independent roles of cyclin D1.
  • To explore the implications of these novel functions in tumorigenesis.

Main Methods:

  • Literature review of existing studies on cyclin D1.
  • Analysis of research on cyclin D1's interaction with transcription factors and chromatin remodeling proteins.

Related Experiment Videos

  • Examination of studies investigating cyclin D1's roles in cellular metabolism, differentiation, and migration.

    • Main Results:

    • Cyclin D1 regulates transcription factors, coactivators, and chromatin remodeling proteins.
    • Cyclin D1 exhibits CDK-independent functions in cellular metabolism, fat cell differentiation, and migration.
    • These novel functions are increasingly recognized for their potential role in cancer development.

    Conclusions:

    • Cyclin D1 possesses both canonical CDK-dependent and non-canonical CDK-independent functions.
    • The CDK-independent roles of cyclin D1 in cellular processes like metabolism and migration are significant for understanding its role in tumorigenesis.
    • Further research into these novel functions may reveal new therapeutic strategies for cyclin D1-associated cancers.