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The arsenical ATPase efflux pump mediates tellurite resistance
R J Turner1, Y Hou, J H Weiner
1Department of Biochemistry, University of Alberta, Edmonton, Canada.
Journal of Bacteriology
|May 1, 1992
Abstract:
The ars operon of the resistance plasmid R773 was found to produce moderate levels of resistance to tellurite. A MIC of 64 micrograms of TeO3(2-) per ml was found for Escherichia coli cells harboring plasmids which contained all three of the structural genes (arsA, arsB, and arsC) of the anion-translocating ATPase. MICs specified by plasmids carrying only one or two structural elements or the cloning vector alone were 2 to 4 micrograms/ml. The rate of TeO3(2-) uptake was found to be on the order of 55% less for cultures containing the resistance plasmids.