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[Gastrointestinal cancer].

Yutaka Takahashi1

  • 1Dept of Surgical Oncology, Cancer Research Institute, Kanazawa University.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 31, 2004
PubMed
Summary

Postoperative monitoring of Carcinoembryonic antigen (CEA) and Cancer antigen 19-9 (CA 19-9) effectively predicts gastric cancer recurrence. Elevated preoperative levels of these tumor markers indicate a higher likelihood of recurrence detection post-surgery.

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Area of Science:

  • Oncology
  • Biomarkers
  • Gastrointestinal Cancer Research

Context:

  • Various tumor markers like SCC, TPA, IAP, CEA, CA 19-9, AFP, CA 125, CA 72-4, and NCC-ST-439 have established roles in diagnosing and staging gastrointestinal cancers.
  • While some markers show utility in specific cancer types (e.g., CEA and CA 19-9 for gastric and colon cancer), their preoperative sensitivity can be limited.

Purpose:

  • To evaluate the efficacy of postoperative monitoring of Carcinoembryonic antigen (CEA) and Cancer antigen 19-9 (CA 19-9) for predicting gastric cancer recurrence.
  • To compare the sensitivity of CEA and CA 19-9 in detecting recurrence versus their preoperative diagnostic capabilities.

Summary:

  • Postoperative monitoring of CEA and CA 19-9 in 120 gastric cancer patients revealed significantly higher positivity rates for recurrence (65.8% and 85.0%, respectively) compared to preoperative sensitivities (28.3% and 45.0%).
  • In patients with elevated preoperative CEA and/or CA 19-9 levels, these markers frequently re-elevated upon recurrence, enabling earlier detection of recurrent disease (mean 3.1 months and 2.2 months before diagnostic imaging, respectively).

Impact:

  • CEA and CA 19-9 postoperative monitoring is a valuable tool for predicting gastric cancer recurrence, particularly in patients with high preoperative marker levels.
  • This monitoring strategy can facilitate earlier detection of recurrent gastric cancer, potentially improving patient management and outcomes.

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