Related Experiment Videos

[Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease]

A D Paramonov, S V Moiseev, V V Fomin

    Terapevticheskii Arkhiv
    |August 31, 2004
    PubMed

    Insights

    High homocysteine, C-reactive protein, and fibrinogen levels indicate unstable angina. Their correlation in unstable angina patients suggests homocysteine

    Area of Science:

    • Cardiology
    • Biochemistry
    • Clinical Medicine

    Background:

    • Ischemic heart disease (IHD) encompasses various clinical presentations.
    • Biomarkers like homocysteine, C-reactive protein (CRP), and fibrinogen are implicated in cardiovascular disease.
    • Understanding their role in different IHD forms is crucial for risk stratification.

    Purpose of the Study:

    • To investigate the clinical significance of elevated homocysteine, CRP, and fibrinogen.
    • To assess these markers across diverse forms of ischemic heart disease.
    • To determine correlations between these markers and disease severity.

    Main Methods:

    • Serum concentrations of homocysteine, CRP, and fibrinogen were measured using enzyme immunoassay.
    • 60 IHD patients (stable effort angina, painless myocardial ischemia, unstable angina) and 20 controls were studied.
    • Myocardial ischemia was confirmed via dobutamine stress echocardiography.

    Main Results:

    • Patients with unstable angina exhibited higher serum levels of homocysteine, CRP, and fibrinogen compared to other IHD groups.
    • A significant correlation was observed between homocysteine and acute phase proteins (CRP, fibrinogen) exclusively in unstable angina patients.
    • No such correlation was found in stable effort angina or painless myocardial ischemia groups.

    Conclusions:

    • Elevated homocysteine, CRP, and fibrinogen are associated with unstable angina.
    • The correlation between homocysteine and acute phase proteins in unstable angina suggests homocysteine's role in atherosclerotic plaque destabilization.
    • This highlights homocysteine's potential involvement in acute coronary syndromes.
    Abstract

    Related Concept Videos

    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

    Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

    Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
    These markers indicate stress or strain on the heart muscle:
    Natriuretic Peptides (BNP)
    Cardiac myocytes produce these hormones in response to ventricular stretching...
    Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

    Blood Studies for Cardiovascular System I: Cardiac Biomarkers

    Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
    The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
    Troponins
    Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
    Acute Coronary Syndrome I: Introduction01:30

    Acute Coronary Syndrome I: Introduction

    Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
    Acute Coronary Syndrome III: Diagnostic Studies01:30

    Acute Coronary Syndrome III: Diagnostic Studies

    Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
    Acute Inflammation III: Local and Systemic Effects01:25

    Acute Inflammation III: Local and Systemic Effects

    Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

    Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

    The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...