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Related Experiment Videos

[Cerebrovascular complications in metabolic syndrome: possible approaches to decrease risk].

I E Chazova, V B Mychka, K M Mamyrbaeva

    Terapevticheskii Arkhiv
    |August 31, 2004
    PubMed
    Summary

    Enoxaparin therapy improved brain perfusion in hypertensive patients with type 2 diabetes mellitus (DM2). This treatment may help prevent cerebrovascular complications in patients with DM2 or metabolic syndrome (MS) and hypertension.

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    [Antihypertensive therapy in patients with arterial hypertension and concomitant diseases in real clinical practice (according to the National Registry of Arterial Hypertension, 2019-2022)].

    Terapevticheskii arkhiv·2024

    Area of Science:

    • Neurology
    • Cardiology
    • Endocrinology

    Background:

    • Hypertension (AH) is a significant risk factor for cerebrovascular disease.
    • Diabetes Mellitus Type 2 (DM2) and Metabolic Syndrome (MS) exacerbate AH complications, including impaired brain perfusion.
    • Cerebral blood flow abnormalities are common in hypertensive patients with DM2 or MS.

    Purpose of the Study:

    • To compare brain perfusion in hypertensive patients with DM2 or MS versus those without these conditions.
    • To investigate the effects of enoxaparin on brain perfusion in patients with DM2 and AH.

    Main Methods:

    • Seventy patients were categorized into three groups: DM2 with AH, MS with AH, and AH alone.
    • Brain perfusion was assessed using single-photon emission computed tomography (SPECT).

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  • Carbohydrate and lipid metabolism were analyzed, alongside a stress test with acetasolamide.

    • Main Results:

    • Brain perfusion was significantly reduced in hypertensive patients with DM2 or MS compared to those with normal metabolism.
    • Hypertensive patients with DM2 exhibited defective cerebral blood flow autoregulation.
    • Six weeks of enoxaparin treatment led to significant improvements in brain perfusion for hypertensive DM2 patients.

    Conclusions:

    • Enoxaparin demonstrates potential in improving brain perfusion in hypertensive patients with DM2 and MS.
    • Enoxaparin therapy may serve as a preventive measure against cerebrovascular complications in this patient group.