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Updated: Aug 22, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
[Amiodarone (cordarone) efficiency in atrial extrasystole]
Aim:
To assess antiarrhythmic amiodarone efficacy of suppressing atrial extrasystoles resistant to other antiarrhythmic modalities.
Material And Methods:
The antiarrhythmic effect of amiodarone was studied in 70 patients (38 males, 32 females, mean age 49.6 +/- 1.7 years, mean duration of arrhythmia 4.9 +/- 1.5 years). The loading oral dose of amiodarone was 600-1200 mg/day for 10 days, mean maintenance dose--1656.25 mg a week, mean duration of treatment--27.5 +/- 3.2 months. The response to amiodarone was estimated by repeated 24-h Holter monitoring.
Results:
A complete response was observed in 78.5% patients in loading and in 65.7% patients in maintenance therapy. A partial antiarrhythmic response was seen in 8.57 and 16.41% patients, respectively.
Conclusion:
Amiodarone is a basic drug against ventricular arrhythmia. Its effectiveness in suppression of atrial extrasystole is weaker but also appropriate.
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