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A Microscopic Phenotypic Assay for the Quantification of Intracellular Mycobacteria Adapted for High-throughput/High-content Screening
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Immunomodulating activity of rifampicin

H M Ziglam1, I Daniels, R G Finch

  • 1Department of Infection & Immunodeficiency, Ninewells University Hospital & Medical School, Dundee, UK. hziglam@yahoo.co.uk

Journal of Chemotherapy (Florence, Italy)
|August 31, 2004
PubMed
Summary

Rifampicin alters human monocyte cytokine production. This antibiotic significantly inhibits interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) while increasing interleukin-6 (IL-6) and interleukin-10 (IL-10) secretion, demonstrating immunomodulatory effects.

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