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Related Experiment Videos

Objective determination of appropriate reporting intervals.

Tony Badrick1, Susan R Wilson, Goce Dimeski

  • 1Sullivan, Nicolaides Pathology, Taringa, Queensland 4068, Australia. Tony.Badrick@snp.com.au

Annals of Clinical Biochemistry
|August 31, 2004
PubMed
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Laboratory reporting intervals are often too narrow, failing to account for analytical imprecision and biological variability. This study highlights the need for revised reporting intervals to ensure accurate analyte concentration reporting.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Science

Background:

  • Reporting intervals define the increments for reporting analyte concentrations.
  • Current reporting intervals are frequently too narrow, disregarding analytical imprecision and biological variability.

Purpose of the Study:

  • To statistically determine appropriate reporting intervals for analytes.
  • To assess the adequacy of current reporting intervals against analytical differences.

Main Methods:

  • Employed statistical techniques to establish 50% and 95% confidence intervals for analytical difference.
  • Compared derived intervals with existing reporting intervals for general chemistry and immunoassay analytes.

Main Results:

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  • No analytes met the 95% confidence criteria for analytical difference.
  • At 50% confidence, 24 of 46 analytes failed criteria across all concentrations.
  • Some analytes, like hormones, require reporting interval increases of tenfold or more.

Conclusions:

  • Most analytes are reported using inappropriate intervals when considering analytical precision.
  • The 'uncertainty of measurement' concept is inadequately addressed in current practices.
  • A consensus on appropriate reporting intervals for all analytes is necessary.