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Lung lysophospholipase activity in specific-pathogen-free rats infected with Pasteurella pneumotropica or Mycoplasma
Abstract:
The effects of Pasteurella pneumotropica and Mycoplasma pulmonis infections in specific-pathogen-free rats were studied to determine whether or not bacterial infections could cause an increase in rat lung lysophospholipase activity and/or changes in bone marrow eosinophil levels. Lung lysophospholipase activity levels of M. pulmonis-infected rats were elevated with increasing infection dosages, but enzyme levels were not accompanied by a lung tissue eosinophilia or an increase in bone marrow eosinophils. Rats infected with P. pneumotropica showed neither an increased lung lysophospholipase activity level nor an increased tissue or bone marrow eosinophilia.
Insights
Mycoplasma pulmonis infection in rats increased lung lysophospholipase activity but did not affect eosinophil levels. Pasteurella pneumotropica infection did not alter lysophospholipase activity or eosinophil counts in rats.
Area of Science:
- Veterinary Pathology
- Immunology
- Biochemistry
Background:
- Bacterial infections can impact host physiology.
- Lysophospholipase activity and eosinophil levels are indicators of inflammatory responses.
Purpose of the Study:
- To investigate the effects of Mycoplasma pulmonis and Pasteurella pneumotropica infections on rat lung lysophospholipase activity.
- To determine if these bacterial infections alter bone marrow eosinophil levels.
Main Methods:
- Specific-pathogen-free rats were infected with M. pulmonis or P. pneumotropica.
- Lung lysophospholipase activity was measured.
- Bone marrow eosinophil counts were assessed.
Main Results:
- Mycoplasma pulmonis infection dose-dependently increased lung lysophospholipase activity.
- Neither M. pulmonis nor P. pneumotropica infections led to lung tissue eosinophilia or increased bone marrow eosinophils.
- P. pneumotropica infection did not affect lung lysophospholipase activity.
Conclusions:
- Mycoplasma pulmonis infection elevates rat lung lysophospholipase activity without inducing eosinophilia.
- Pasteurella pneumotropica infection does not impact rat lung lysophospholipase or eosinophil levels.