Serrated adenomas of the appendix.

Area of Science:

• Gastroenterology
• Surgical Pathology
• Oncology

Background:

• Literature review revealed only one prior case of appendiceal serrated adenoma.
• Appendiceal neoplasms are rare, necessitating further investigation into their pathology.

Purpose of the Study:

• To investigate the occurrence and characteristics of serrated adenomas in the appendix.
• To compare the aggressiveness of appendiceal serrated adenomas with their colorectal counterparts.

Main Methods:

• Retrospective review of 38 surgically removed non-carcinoid, neoplastic, or non-neoplastic appendiceal polyps and tumors.
• Histopathological analysis of all available hematoxylin and eosin stained sections.

Main Results:

• Serrated adenomas constituted 10 of 38 appendiceal lesions.
• Four of the 10 serrated adenomas had progressed to invasive carcinoma at the time of resection.
• Appendiceal serrated and villous adenomas demonstrated high aggressiveness, exceeding that of similar colorectal lesions.

Conclusions:

• Serrated adenomas are a significant finding among appendiceal neoplasms.
• Appendiceal serrated adenomas appear to be more aggressive than colorectal serrated adenomas.
• Further research is needed to determine if hyperplastic polyps in the appendix can evolve into serrated adenomas, similar to the colon and rectum.