Related Experiment Videos
Correlation between serum E-selectin levels and panoramic nailfold capillaroscopy in systemic sclerosis
V Valim1, L S S Assis, M F J Simões
1Divisão de Reumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil. vvalim@ebrnet.com.br
Summary
Serum E-selectin levels correlate with nailfold capillaroscopy changes in systemic sclerosis patients. This suggests soluble E-selectin may indicate early disease activity and vascular damage.
Area of Science:
- Vascular Biology
- Rheumatology
- Biomarker Discovery
Background:
- E-selectin, expressed by activated endothelium, is elevated in systemic sclerosis.
- Nailfold capillaroscopy reveals microvascular abnormalities in systemic sclerosis.
Purpose of the Study:
- To investigate the association between serum E-selectin levels and nailfold capillaroscopic findings in systemic sclerosis patients.
- To explore E-selectin as a potential biomarker for disease activity.
Main Methods:
- Serum E-selectin levels were measured using ELISA in 18 systemic sclerosis patients.
- Nailfold capillaroscopy assessed capillary deletion and ectasia.
- Statistical analysis included Student t-test and Spearman correlation.
Main Results:
- A significant correlation was found between serum E-selectin levels and capillary deletion score (r = 0.50, P < 0.035).
- This correlation was stronger in early disease (within 48 months of diagnosis) (r = 0.63, P < 0.048).
- No significant association was observed between E-selectin and capillary ectasia.
Conclusions:
- Soluble serum E-selectin levels correlate with specific capillaroscopic alterations in systemic sclerosis.
- Serum E-selectin may serve as a valuable biochemical marker for early systemic sclerosis activity, particularly related to capillary deletion.