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Vertebral telangiectatic osteosarcoma in a dog.
G Brellou1, N Papaioannou, M Patsikas
1Department of Veterinary Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
Veterinary Clinical Pathology
|August 31, 2004
Summary
A rare telangiectatic osteosarcoma (TOS) was found in a dog
Area of Science:
- Veterinary Pathology
- Canine Oncology
Background:
- Osteosarcoma is a common primary bone tumor in dogs.
- Telangiectatic osteosarcoma (TOS) is a rare subtype characterized by prominent vascular spaces.
Observation:
- A 4-year-old male dog presented with locomotor dysfunction.
- Radiographs and myelograms revealed bone lysis and an extradural-extramedullary mass at the C7 vertebra.
- Histopathology confirmed a tumor with blood-filled cavities and anaplastic stromal cells.
Findings:
- The tumor exhibited features consistent with telangiectatic osteosarcoma.
- Immunohistochemistry showed tumor cells positive for proliferating cell nuclear antigen.
- Tumor cells lining cystic spaces were negative for von Willebrand factor, aiding in differential diagnosis.
Implications:
- This case highlights TOS as a differential diagnosis for spinal masses in dogs.
- Immunohistochemistry is valuable for diagnosing TOS and assessing malignancy.
- Findings are comparable to human TOS, suggesting shared biological characteristics.