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[Protection of babies born to HBsAg(+) mothers]
M Satar1, N Savaş, M N Kozanoğlu
1Cukurova Universitesi Tip Fakültesi Cocuk Sağliği ve Hastaliklari Anabilim Dali.
Insights
Passive and active immunization with Hepatitis B immune globulin (HBIG) and Hepatitis B virus (HBV) vaccine effectively protected infants born to HBsAg-positive mothers. Immunized infants showed high anti-HBs positivity, while unvaccinated infants remained HBsAg negative.
Area of Science:
- Hepatology
- Immunology
- Pediatrics
Context:
- Hepatitis B virus (HBV) infection poses a significant risk to newborns born to infected mothers.
- Vertical transmission of HBV can lead to chronic infection and serious liver disease in infants.
- Effective immunization strategies are crucial for preventing perinatal HBV transmission.
Purpose:
- To evaluate the efficacy of combined passive and active immunization against Hepatitis B virus (HBV) in infants born to HBsAg-positive mothers.
- To assess the seroprotection rates and prevention of HBsAg positivity in immunized infants compared to a control group.
Summary:
- Infants born to HBsAg-positive mothers received either passive immunization with Hepatitis B immune globulin (HBIG) and active immunization with the HBV vaccine, or no immunization (control group).
- A total of 24 infants were followed for 12-18 months.
- 76.4% of immunized infants achieved protective anti-HBs antibody levels by 12 months.
- None of the infants in the control group (unimmunized) became HBsAg positive within the 12-month follow-up period.
Impact:
- This study demonstrates the high effectiveness of combined HBIG and HBV vaccine administration in preventing Hepatitis B infection in infants born to HBsAg-positive mothers.
- The findings support current vaccination guidelines for perinatal Hepatitis B prevention.
- Successful immunization reduces the long-term risk of chronic liver disease and hepatocellular carcinoma in high-risk infants.
Abstract:
Babies of 17 HBsAg positive mothers were passively and actively immunized with HBIG and HBV vaccine. Seven infants born from HBsAg (+) mothers were not immunized with their families decisions and used as control group. 24 infants were followed for 12-18 months. 76.4% of immunized babies were anti-HBs positive at 12 months. None of the babies who were not immunized were HBsAg positive at 12 months.