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Updated: Aug 22, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Is the nasopharynx warmer in children than in adults?
N C Molony1, A I Kerr, C C Blackwell
1Department of Otolaryngology, Lauriston Building, The Royal Infirmary, University of Edinburgh, Edinburgh, UK.
Insights
Sudden Infant Death Syndrome (SIDS) may be linked to bacterial toxins produced at high temperatures. This study measured nasopharyngeal temperatures, finding children
Area of Science:
- Pediatrics
- Microbiology
- Toxicology
Background:
- Sudden Infant Death Syndrome (SIDS) etiology is multifactorial.
- Pyrogenic toxins from bacteria like Staphylococcus aureus may contribute to SIDS via inflammatory responses.
- Staphylococcus aureus toxin production requires temperatures above 37°C.
Purpose of the Study:
- To investigate nasopharyngeal temperatures in children.
- To develop accurate methods for measuring nasopharyngeal temperature in infants during the SIDS-vulnerable age range.
- To assess the proximity of nasopharyngeal temperature to 37°C.
Main Methods:
- Preliminary study with power calculation.
- Nasopharyngeal temperature measurements using a thermocouple probe.
- Subjects included 30 children (4-10 years) and 30 adults undergoing general anesthesia.
Main Results:
- Mean nasopharyngeal temperature in children was 35.64°C.
- Mean nasopharyngeal temperature in adults was 34.01°C.
- Childhood nasopharyngeal temperatures were significantly higher than adult temperatures.
Conclusions:
- Children exhibit higher nasopharyngeal temperatures than adults.
- This finding has implications for understanding SIDS risk related to bacterial toxin production.
- Further research is needed to validate these findings in infants.
Abstract:
Recent studies on the aetiology of the Sudden Infant Death Syndrome (SIDS) have suggested that some of these deaths are the consequence of an overwhelming inflammatory response to the production of pyrogenic toxins from bacteria colonizing the upper respiratory tract, particularly the nasopharynx. The pyrogenic toxins of Staphlococcus aureus, one of the likelier bacterial candidates, are only produced in temperatures of over 37 degrees C. This study examined nasopharyngeal temperatures in children. It is a preliminary study to develop an accurate means to measure how close to 37 degrees C the nasopharyngeal temperature lies in infants at the age when SIDS deaths occur. Following a pilot study and power calculation, measurements of nasopharyngeal temperature were made on 30 apyrexial children aged 4-10 years and 30 adults with no nasal pathology, undergoing surgery under general anaesthesia, using an accurately sited thermocouple probe. The mean temperature in children (35.64 degrees C) was significantly higher than in adults (34.01 degrees C). Comparable measurements attempted with the same subjects awake gave similar results.
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