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What's new in the IGF-binding proteins?
1Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29403, USA. rosenzsa@musc.edu
Summary
Insulin-like growth factor binding proteins (IGFBPs) were initially thought to only carry IGFs. Recent research reveals these IGFBP proteins have diverse biochemical and cell biological functions beyond simple ligand transport.
Area of Science:
- Biochemistry
- Cell Biology
- Endocrinology
Background:
- The insulin-like growth factor binding protein (IGFBP) family comprises six members, discovered over 25 years ago.
- IGFBPs bind IGF-I and IGF-II with higher affinity than the IGF-IR, leading to the assumption they block ligand-receptor access.
- IGFs are constitutively secreted by many cell types, necessitating regulatory proteins.
Purpose of the Study:
- To review the known and newly discovered functions of IGFBPs.
- To examine IGFBP actions from biochemical and cell biological viewpoints.
Main Methods:
- Literature review of biochemical and cell biological studies on IGFBPs.
- Analysis of existing data on IGFBP interactions and functions.
Main Results:
- IGFBPs possess functions beyond merely binding IGF ligands.
- Emerging evidence highlights diverse roles for IGFBPs in cellular processes.
Conclusions:
- The IGFBP family exhibits multifaceted roles in biological systems.
- Further investigation into the biochemical and cell biological actions of IGFBPs is warranted.