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A genome-wide and nonredundant mouse transcription factor database
Mutsumi Kanamori1, Hideaki Konno, Naoki Osato
1Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.
Biochemical and Biophysical Research Communications
|September 1, 2004
Summary
Researchers developed a comprehensive mouse transcription factor database, identifying key regulators and their properties. This resource aids systematic studies of genome-wide transcriptional regulation.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Transcription factors (TFs) are crucial regulators of gene expression.
- Understanding TF networks is essential for deciphering cellular processes.
- Existing resources may lack comprehensive, nonredundant coverage of mouse TFs.
Purpose of the Study:
- To create a genome-wide, nonredundant database of mouse transcription factors and their regulators.
- To develop a viewer for easy access and exploration of the TF database.
- To facilitate systematic genome-wide studies of transcriptional regulation.
Main Methods:
- Systematic selection of TFs with DNA-binding properties and their regulators.
- Utilized LocusLink and Gene Ontology annotations for TF identification.
- Incorporated information on available cDNA clones and structural properties.
Main Results:
- Developed a unique, nonredundant genome-wide mouse transcription factor database.
- Integrated data on TF DNA-binding properties, regulators, and cDNA clone information.
- Created a viewer for the database (http://genome.gsc.riken.gp/TFdb/).
- The database provides valuable information for systematic genome-wide studies.
Conclusions:
- The developed mouse TF database is a unique and valuable resource.
- It supports systematic research into transcriptional regulation.
- Facilitates further investigation into TF networks and their functions.