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Related Experiment Videos

Fgf18 is required for embryonic lung alveolar development.

Hiroko Usui1, Masaki Shibayama, Norihiko Ohbayashi

  • 1Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606-8501, Japan.

Biochemical and Biophysical Research Communications
|September 1, 2004
PubMed
Summary

Fibroblast growth factor 18 (Fgf18) plays a crucial role in mouse embryonic lung development, particularly in alveolar formation. Its absence impacts alveolar space and capillary development during late stages.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Pulmonology

Background:

  • Fibroblast growth factor 18 (Fgf18) is highly expressed during embryonic lung development.
  • Understanding Fgf18's function is key to deciphering lung morphogenesis.

Purpose of the Study:

  • To investigate the specific roles of Fgf18 in mouse embryonic lung development.
  • To analyze the impact of Fgf18 deficiency on lung structure and cellular processes.

Main Methods:

  • Comparative analysis of Fgf18 knockout (Fgf18-/-) mouse embryonic lungs versus wild-type.
  • Histological examination of lung architecture, airway branching, and interstitial compartments.
  • Assessment of cell proliferation and gene expression markers.

Main Results:

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  • Fgf18-/- lungs showed no defects in proximal or distal airway branching.
  • Significant reduction in alveolar space and thickened interstitial mesenchymal compartments observed in Fgf18-/- lungs at E18.5.
  • Transient reduction in cell proliferation around E17.5 and increased embedded capillaries in Fgf18-/- lungs.

Conclusions:

  • Fgf18 is essential for proper alveolar development in late-stage embryonic mouse lungs.
  • Fgf18-stimulated cell proliferation during the terminal saccular stage may be critical for distal lung remodeling.