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Updated: Aug 22, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
08:13

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)

Published on: January 7, 2018

Should oral glucose tolerance test be a routine examination after a myocardial infarction?

Loghman Henareh1, Margareta Berglund, Stefan Agewall

  • 1Department of Cardiology, Huddinge University Hospital, Karolinska Institute, S-141 86 Stockholm, Sweden.

International Journal of Cardiology
|September 1, 2004
PubMed

Insights

A high prevalence of diabetes mellitus (DM) and impaired glucose tolerance (IGT) was found in heart attack survivors without prior DM diagnosis. Routine oral glucose tolerance testing is recommended post-myocardial infarction.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Diabetes mellitus (DM) and impaired glucose tolerance (IGT) are established cardiovascular risk factors.
  • Patients recovering from myocardial infarction (MI) often have undiagnosed glucose metabolism abnormalities.

Purpose of the Study:

  • To determine the prevalence of DM and IGT in patients discharged from cardiac care units (CCU) after MI, who had no prior DM diagnosis.

Main Methods:

  • 110 patients (31-80 years) with MI 1-12 months prior underwent an oral glucose tolerance test (OGTT).
  • Patients with pre-existing DM were excluded from the study.
  • A standard 75g oral glucose challenge was administered.

Main Results:

  • The study identified IGT in 26% (29/110) and DM in 12% (13/110) of patients via OGTT.
  • Fasting plasma glucose (FPG) alone detected only 19% of patients with abnormal glucose tolerance.
  • Overall, 38% of patients without known DM had pathological glucose tolerance post-MI.

Conclusions:

  • Pathological glucose tolerance is a significant cardiovascular risk factor following myocardial infarction.
  • Oral glucose tolerance testing (OGTT) should be considered a routine screening tool for patients post-MI without a known DM diagnosis.
Abstract

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