Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular evolution of NPY receptor subtypes.

D Larhammar1, E Salaneck

  • 1Department of Neuroscience, Unit of Pharmacology, Box 593 Uppsala University, SE-75124 Uppsala, Sweden. dan.larhammar@neuro.uu.se

Neuropeptides
|September 1, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Globalization of Traditional Chinese Medicine: what are the issues for ensuring evidence-based diagnosis and therapy?

Journal of internal medicine·2019
Same author

Assessing and regulating homeopathic products.

Journal of internal medicine·2017
Same author

Characterization of the neuropeptide Y system in the frog Silurana tropicalis (Pipidae): three peptides and six receptor subtypes.

General and comparative endocrinology·2012
Same author

Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization.

Gene·2008
Same author

Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages.

Gene·2006
Same author

Cloning and characterization of a zebrafish Y2 receptor.

Regulatory peptides·2005

The neuropeptide Y (NPY) system

Area of Science:

  • Evolutionary biology
  • Neuroendocrinology
  • Genomics

Background:

  • The neuropeptide Y (NPY) system, crucial for appetite and anxiety, exhibits complex evolution across vertebrates.
  • Vertebrate ancestors likely possessed a single NPY peptide gene and three Y receptor genes.

Purpose of the Study:

  • To investigate the evolutionary history and gene repertoire of the NPY system in vertebrates.
  • To understand gene duplication and loss events shaping NPY receptor diversity.
  • To explore functional implications of gene loss in mammals and teleost fishes.

Main Methods:

  • Comparative genomics analysis of NPY system genes across vertebrate lineages.
  • Phylogenetic reconstruction to infer ancestral gene content and duplication events.

Related Experiment Videos

  • Analysis of gene loss patterns and their potential functional consequences.

    • Main Results:

    • Ancestral gnathostomes likely had two peptide genes (NPY, PYY) and at least seven Y receptor genes.
    • Mammals have lost Yb and Y7 receptors, with Y6 being a pseudogene in some species.
    • Teleost fishes lost appetite-stimulating Y1 and Y5 receptors, suggesting alternative pathways for NPY signaling.

    Conclusions:

    • Vertebrate NPY system evolution is characterized by gene duplication and differential gene loss.
    • Mammalian and teleost fish lineages have undergone distinct gene losses, impacting NPY system functions.
    • Further research is needed to understand functional compensation and adaptation in NPY signaling pathways.